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于2025年5月发表在《Nature genetics》上的“The multilayered transcriptionalarchitecture of glioblastoma ecosystems”。利用单核RNA测序和DNA测序，对异柠檬酸脱氢酶野生型胶质母细胞瘤（GBM）的多层转录结构进行了深入分析。研究人员发现了三种新的恶性细胞状态，并识别了三种基线基因表达模式，这些模式在肿瘤之间存在差异，但在一开始便存在于肿瘤内部的各种细胞状态中。此外，该研究还探讨了肿瘤微环境和遗传变异如何影响GBM的细胞状态和基线模式，最终定义了三种典型的GBM生态系统，揭示了该疾病的复杂异质性。
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