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Evo 2，这是一种生物基础模型，旨在理解和设计生命所有领域的基因组。它通过分析9.3万亿个核苷酸标记，能够预测突变对蛋白质、RNA和生物体适应性的影响，并在生成新的基因组序列方面表现出色。Evo 2 的创新之处在于，它能在分子到基因组的尺度上进行泛化，并通过稀疏自编码器揭示生物学特征，即便对于已灭绝物种的基因组也能进行功能性基因组注释。该研究还展示了如何利用该模型进行可控的基因组设计，例如编码表观基因组中的摩尔斯电码信息，标志着计算生物学领域的重大进步。Reference: Genome modeling and design across all domains of life with Evo 2bioRxiv 2025.02.18.638918; doi: Evo 2
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