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聊聊Sci

011-“超级杀伤”细胞治疗自身免疫病前景广阔🛡️

07 Jul 2025

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这些文章共同探讨了自身免疫性疾病的最新研究进展,这是一种免疫系统错误攻击自身组织的疾病。其中,一篇报道展望了治愈这些疾病的希望,特别是通过恢复免疫“耐受性”的新疗法。另一篇文章聚焦于嵌合抗原受体T细胞(CAR-T)疗法,这种最初用于治疗癌症的方法,已显示出在自身免疫性疾病治疗中的巨大潜力,使患者症状缓解甚至进入缓解期。此外,还有文章介绍了经过基因改造的“自然杀伤”细胞,作为CAR-T疗法更经济、更易得的替代方案。最后,一篇报道揭示了女性自身免疫性疾病发病率更高的原因,指向了X染色体上的一种分子涂层可能引发不必要的免疫反应。References: 1. https://www.nature.com/articles/d41586-025-02096-7 2. https://www.nature.com/articles/d41586-023-03968-6 3. https://www.nature.com/articles/d41586-024-00169-7 4. https://www.nature.com/articles/d41586-024-00267-6 5. Wang X, Zhang Y, Jin Y, et al. An iPSC-derived CD19/BCMA CAR-NK therapy in a patient with systemic sclerosis[J]. Cell, 2025.

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