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聊聊Sci

014-小鼠嗅球的三维分子结构🧠

10 Jul 2025

Description

本研究详细阐述了小鼠嗅球的三维分子结构,并精准定位了数百个嗅小球,这些嗅小球是处理嗅觉信息的功能单元。通过三维空间转录组学,研究人员绘制了嗅小球的分子图谱,揭示了其在嗅球半球之间和每个半球内部的高度对称性。研究发现,嗅小球的对称性并未延伸至深层的僧帽细胞和颗粒细胞,这表明从感觉输入到皮层输出的通路存在重组。此外,研究还发现嗅觉上皮中的基因表达模式能高精度地预测嗅小球的位置,这为理解大脑的对称性如何被分子结构所指导提供了新见解。Reference: Klimpert N, Kollo M, Brann DH, Tan C, Barry D, Ma Y, Schaefer AT, Fleischmann A. 3D spatial transcriptomics reveals the molecular structure of input and output pathways in the mouse olfactory bulb. bioRxiv [Preprint]. 2025 Apr 23:2025.02.19.639192. doi: 10.1101/2025.02.19.639192. PMID: 40060607; PMCID: PMC11888228.

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