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这篇发布于《自然》杂志的文章深入探讨了肥胖和体重减轻对人类脂肪组织（AT）的复杂影响。研究人员通过分析来自肥胖患者（减重前后）和健康瘦体型个体的单核和空间图谱，揭示了肥胖如何导致脂肪细胞、祖细胞和血管细胞的选择性衰老和功能障碍。文章强调，体重减轻能够有效逆转这些有害变化，改善代谢健康，但同时也发现，肥胖引起的巨噬细胞激活状态可能部分持续存在，这可能与体重反弹和代谢功能障碍有关。References: Miranda, A.M.A., McAllan, L., Mazzei, G. et al. Selective remodelling of the adipose niche in obesity and weight loss. Nature (2025). doi.org
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