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聊聊Sci

018-重塑癌症中的2型免疫♋

15 Jul 2025

Description

本篇文章是关于肿瘤中2型免疫的再探索”是Marek Wagner、Hiroyoshi Nishikawa和Shigeo Koyasu撰写并发表在《自然》杂志上的一篇综述,探讨了2型免疫在癌症治疗中的潜在作用。该综述挑战了2型免疫促进肿瘤发生的传统观点,提出其可能抑制肿瘤生长并为新型癌症免疫疗法提供机会。文章强调了对2型免疫新功能的理解,并探讨了它在寄生虫感染防御、组织修复和脂肪组织稳态方面的多重作用。此外,它还讨论了ILC2s、嗜酸性粒细胞、B细胞和肥大细胞等免疫细胞在肿瘤微环境中的复杂相互作用,表明它们在抗肿瘤免疫反应中具有重要潜力。References: Wagner, M., Nishikawa, H. & Koyasu, S. Reinventing type 2 immunity in cancer. Nature 637, 296–303 (2025). doi.org

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