这篇文章概述了神经-免疫系统在胶质瘤免疫疗法中的复杂相互作用。它解释了中枢神经系统（CNS）不再被认为是免疫特权区，而是拥有独特的免疫微环境，对大脑健康和CNS肿瘤的免疫疗法具有重要影响。文章探讨了不同免疫细胞在CNS及其边界的独特作用，以及它们如何与神经元和星形胶质细胞进行双向交流。文献还回顾了针对高级别胶质瘤（HGGs）的多种免疫疗法策略，包括免疫检查点抑制剂、嵌合抗原受体T细胞（CAR T细胞）疗法、溶瘤病毒和疫苗疗法，并讨论了它们各自的挑战和未来方向。最后，它详细阐述了免疫疗法可能引起的神经毒性，例如细胞因子释放综合征（CRS）和免疫效应细胞相关神经毒性综合征（ICANS），并强调了优化治疗以实现持久疗效的重要性。References: Song, Kun-Wei, Michael Lim, and Michelle Monje. "Complex neural-immune interactions shape glioma immunotherapy." Immunity 58.5 (2025): 1140-1160.
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