这篇文章概述了一项关于小胶质细胞替代疗法治疗CSF1R相关性小胶质细胞病（ALSP）的研究。该研究首先通过创建模仿人类热点突变的小鼠模型，证明了小胶质细胞替代（MISTER）策略能有效纠正致病性CSF1R突变，从而改善小鼠的脑部病理、运动和认知功能障碍。此外，研究还发现传统骨髓移植（tBMT）在ALSP小鼠和患者体内能有效替代小胶质细胞，并展现出类似的治疗益处。最后，研究通过对八名ALSP患者进行tBMT治疗的临床验证，观察到疾病进展停止，运动和认知功能得到维持。References: Jingying Wu et al. Microglia replacement halts the progression of microgliopathy in mice and humans.Science389,eadr1015(2025).DOI:10.1126/science.adr1015
No persons identified in this episode.
This episode hasn't been transcribed yet
Help us prioritize this episode for transcription by upvoting it.
Popular episodes get transcribed faster
Other recent transcribed episodes
Transcribed and ready to explore now
Trump $82 Million Bond Spree, Brazil Tariffs 'Too High,' More
16 Nov 2025
Bloomberg News Now
Ex-Fed Gov Resigned After Rules Violations, Trump Buys $82 Mil of Bonds, More
16 Nov 2025
Bloomberg News Now
THIS TRUMP INTERVIEW WAS INSANE!
16 Nov 2025
HasanAbi
Epstein Emails and Trump's Alleged Involvement
15 Nov 2025
Conspiracy Theories Exploring The Unseen
New Epstein Emails Directly Implicate Trump - H3 Show #211
15 Nov 2025
H3 Podcast
Trump Humiliates Himself on FOX as They Call Him Out
15 Nov 2025
IHIP News