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聊聊Sci

031-精准老年医学:基因与衰老

28 Jul 2025

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这篇综述讨论了衰老科学和精准老年医学的进步,这两个新兴领域旨在理解和管理人类衰老。文章概述了衰老的标志,即导致生物衰老的分子、细胞和超细胞机制,并引入了促衰老基因和抗衰老基因的概念,它们可以加速或延缓衰老过程。文章进一步探讨了使用多组学技术作为衰老生物标志物,以期为个体化治疗提供基础,并提出了通过靶向衰老本身来预防和治疗年龄相关疾病的策略。最终描绘了精准老年医学的未来前景,强调其在健康个体中进行早期干预以优化健康和延长健康寿命的潜力。References: Kroemer G, Maier A B, Cuervo A M, et al. From geroscience to precision geromedicine: Understanding and managing aging[J]. Cell, 2025, 188(8): 2043-2062.

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