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聊聊Sci

033-RNA损伤响应:机制、疾病与治疗🧬

29 Jul 2025

Description

这篇文章主要探讨细胞对RNA损伤的反应,强调了RNA在生命过程中蛋白质生物合成和各种调控功能的核心作用。文章解释了RNA如何像DNA一样持续受到内源性和环境源的损害,并详细阐述了细胞如何通过复杂的RNA损伤反应机制来应对这些挑战,这对于细胞在核酸损伤剂暴露下的生存以及损伤的修复至关重要。此外,它还讨论了RNA损伤与多种人类疾病之间的关联,包括炎症、癌症和神经退行性疾病,并提出了针对RNA损伤反应网络作为潜在治疗靶点的可能性。References: Cordes J, Zhao S, Engel C M, et al. Cellular responses to RNA damage[J]. Cell, 2025, 188(4): 885-900.

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