本研究提供了一篇关于血管内皮的综合性综述，将其视为一个系统性分布的器官。文章首先介绍了内皮细胞功能障碍在多种疾病，如心血管疾病、癌症和炎症中的核心作用。接着，它详细阐述了血管内皮的生命周期，包括血管生成、血管维持和衰老过程。此外，该综述还探讨了内皮细胞的响应和中继功能，例如其屏障作用、细胞运输调节、血管通透性、血压控制和凝血功能。最后，文章深入分析了内皮细胞的指导性功能，包括机械转导、代谢接口以及通过“血管因子”实现的局部信号传导，并展望了再生医学、预防医学和血管衰老研究在转化血管科学中的前景。References: Augustin H G, Koh G Y. A systems view of the vascular endothelium in health and disease[J]. Cell, 2024, 187(18): 4833-4858.
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