Description
本篇论文介绍了一种癌症细胞状态的发育约束模型，该模型提出癌细胞群体在宿主生物体的发育图谱中移动，从而产生异质性细胞集合。作者探讨了癌细胞状态的复发性、程序共选和细胞可塑性等特性，并分析了这些状态与正常发育谱系之间的对应关系。文章还讨论了该模型与现有癌症模型（如去分化模型和癌症干细胞模型）的关系，并提出了其在预测肿瘤行为和指导治疗策略方面的潜在应用，同时也指出了该模型的局限性。References: Patel A S, Yanai I. A developmental constraint model of cancer cell states and tumor heterogeneity[J]. Cell, 2024, 187(12): 2907-2918.
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