Description
这篇综述探讨了时空组学技术的最新进展，该技术能够同时获取细胞在特定位置上的分子信息。文章首先介绍了时空组学如何克服传统基因组学和单细胞组学在理解细胞异质性与组织结构方面存在的局限性。随后，它详细阐述了成像和测序两大类时空组学方法及其演变，从区域尺度到纳米尺度的分辨率提升。最后，该综述强调了时空组学在生物学和临床上的广泛应用，包括阐明器官功能、揭示发育动力学、理解物种进化以及解析疾病机制，并指出了未来的发展方向和挑战。References: Liu L, Chen A, Li Y, et al. Spatiotemporal omics for biology and medicine[J]. Cell, 2024, 187(17): 4488-4519.
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