这项研究深入探讨了胰腺癌中神经侵袭的细胞和空间特征，利用单细胞和空间转录组学技术分析了不同神经侵袭状态下的胰腺导管腺癌组织。研究人员揭示了低神经侵袭和高神经侵袭组织之间肿瘤微环境的差异，发现低神经侵袭的肿瘤组织中富含与未侵袭神经共定位的三级淋巴结构，而高神经侵袭的组织中，NLRP3+巨噬细胞和肌成纤维细胞围绕着被侵袭的神经。研究还识别出一种独特的TGFBI+ Schwann细胞亚群，该亚群可能通过重塑细胞外基质和粘附到基质来促进肿瘤细胞的迁移和侵袭。此外，研究确定了基底样和GABRP+恶性细胞表现出增强的神经侵袭潜力。这些发现为靶向神经侵袭的治疗策略提供了新的见解。References: Chen M M, Gao Q, Ning H, et al. Integrated single-cell and spatial transcriptomics uncover distinct cellular subtypes involved in neural invasion in pancreatic cancer[J]. Cancer Cell, 2025.
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