细胞衰老是一种稳定的细胞周期停滞状态，由各种内在和外在应激源引起，作为一种保护机制，旨在阻止受损细胞的增殖。尽管这一过程对于组织稳态和肿瘤抑制至关重要，但随着时间的推移，衰老细胞（SnCs）的逐渐积累与年龄相关病理学有关，包括免疫功能障碍和癌症。在肿瘤学中，衰老扮演着矛盾的角色：它可以通过阻止潜在恶性细胞的生长来抑制肿瘤发展，但也可以通过衰老相关分泌表型（SASP）促进肿瘤进展。本综述探讨了癌症中衰老的定义特征、其与肿瘤细胞、基质和免疫系统的复杂相互作用，以及其背景依赖性结果。这篇文章还讨论了当前和新兴的靶向SnCs的治疗策略：通过诱导或清除它们，以及用于在癌症中检测和表征SnCs的AI驱动方法。References: Colucci M, Sarill M, Maddalena M, et al. Senescence in cancer[J]. Cancer Cell, 2025.
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