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聊聊Sci

048-个性化癌症疫苗的未来

13 Aug 2025

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基因组学引导的私人定制癌症疫苗 (PCV) 在早期临床研究中展现出在多种恶性肿瘤、临床环境和治疗方案中诱导长期、肿瘤特异性免疫反应的潜力。随着PCV进入大规模、随机临床试验阶段,我们正处于一个关键时期。PCV未来的成功将取决于我们能否集体应用并迭代早期和正在进行的深入研究的基础经验教训,从而合理利用PCV的细胞溶解能力来根除晚期癌症,在辅助治疗环境中治愈患者,并预防高危患者恶性肿瘤的发展。现代下一代测序和创新临床生物信息学平台的出现,推动了靶向新抗原的基因组学引导PCV的发展。References: Martini D J, Wu C J. The Future of Personalized Cancer Vaccines[J]. Cancer Discovery, 2025, 15(7): 1315-1324.

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