本研究探讨了干细胞疗法在治疗糖尿病方面的潜力，重点关注如何从人类多能干细胞中培育出胰岛样细胞。hPS细胞衍生的胰岛/β细胞疗法代表着糖尿病治疗的“极其激动人心和充满希望的前沿”。文章详细回顾了这一领域的科学进展，包括优化β细胞分化方案以提高其功能和产量。此外，它还讨论了正在进行的临床试验的成果，强调了不同移植策略和免疫逃逸技术的重要性。尽管在分化协议、临床应用和免疫逃逸策略方面取得了显著进展，但仍面临规模化生产、低温保存技术和协调全球监管标准等挑战。未来的成功将需要科学家、医生、监管机构和患者群体之间的密切合作，以克服系统性障碍，最终为胰岛素依赖型患者提供改变生命的治疗方案。最后，文章着重分析了与人类干细胞衍生产品相关的生物制造挑战和监管考量，为未来的糖尿病细胞疗法描绘了发展蓝图。References: Chen J T, Dadheech N, Tan E H P, et al. Stem cell therapies for diabetes[J]. Nature Medicine, 2025: 1-14.
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