这篇综述深入探讨了细胞毒性IgG抗体的作用机制、功能及其在治疗恶性、自身免疫和感染性疾病中的应用。文章详细阐述了抗体依赖性细胞毒性（ADCC）、抗体依赖性细胞吞噬（ADCP）、补体依赖性细胞毒性（CDC）以及其他IgG介导的细胞杀伤途径。它强调了Fcγ受体（FcγRs）在不同效应细胞和组织环境中的表达模式，以及IgG亚类如何通过与FcγRs的结合差异来调节细胞毒性活性。此外，文章还讨论了目标抗原的特性和肿瘤微环境对IgG细胞毒性作用的影响，并提出了增强IgG治疗效果的潜在策略，例如阻断抑制性信号或招募更多的效应细胞。References: Wöhner M, Nimmerjahn F. Cytotoxic IgG: Mechanisms, functions, and applications[J]. Immunity, 2025, 58(6): 1378-1395.
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