这篇综述探讨了阿尔茨海默病 (AD) 和 年龄相关性黄斑变性 (AMD) 这两种主要影响老年人群的神经退行性疾病，尽管它们分别导致认知障碍和视力损害，但却共享神经炎症通路。文章详细阐述了两种疾病在免疫机制、氧化应激、淀粉样蛋白和玻璃膜疣沉积等方面的相似性，以及 APOE 和 ABCA1 等共有风险基因在不同组织中的相反作用。此外，它还比较了 小胶质细胞、巨噬细胞和中性粒细胞 在 AD 和 AMD 病理中的共有及不同作用，并讨论了成年神经发生在脑部和视网膜中的差异。最后，该综述概述了针对这两种疾病的治疗策略进展，强调了跨疾病治疗和诊断方法的潜力，以期通过深入理解其共同的免疫学基础，为未来的研究和临床实践提供新的方向。References: Butovsky O, Rosenzweig N. Alzheimer’s disease and age-related macular degeneration: Shared and distinct immune mechanisms[J]. Immunity, 2025, 58(5): 1120-1139.
No persons identified in this episode.
This episode hasn't been transcribed yet
Help us prioritize this episode for transcription by upvoting it.
Popular episodes get transcribed faster
Other recent transcribed episodes
Transcribed and ready to explore now
Trump $82 Million Bond Spree, Brazil Tariffs 'Too High,' More
16 Nov 2025
Bloomberg News Now
Ex-Fed Gov Resigned After Rules Violations, Trump Buys $82 Mil of Bonds, More
16 Nov 2025
Bloomberg News Now
THIS TRUMP INTERVIEW WAS INSANE!
16 Nov 2025
HasanAbi
Epstein Emails and Trump's Alleged Involvement
15 Nov 2025
Conspiracy Theories Exploring The Unseen
New Epstein Emails Directly Implicate Trump - H3 Show #211
15 Nov 2025
H3 Podcast
Trump Humiliates Himself on FOX as They Call Him Out
15 Nov 2025
IHIP News