这篇文章探讨了小胶质细胞在大脑发育中的关键作用，包括它们如何影响神经祖细胞、神经元、星形胶质细胞和少突胶质细胞的生长和功能。文章强调了TREM2受体的重要性，该受体通过塑造小胶质细胞的转录和功能命运，在神经发生、突触修剪和髓鞘形成等过程中指导靶细胞。文中讨论了TREM2在衰老和神经退行性疾病中的作用，并探究了其在早期大脑发育中对小胶质细胞与各种脑细胞相互作用的潜在影响。文章还指出，尽管缺乏小胶质细胞可能导致补偿机制的激活，但TREM2及其信号通路对维持脑稳态至关重要。References: Morini R, Tagliatti E, Bizzotto M, et al. Microglial and TREM2 dialogues in the developing brain[J]. Immunity, 2025.
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