这篇文章探讨了早期发病结直肠癌 (EOCRC) 发病率的显著上升，强调了胰岛素抵抗 (InsR) 在此趋势中作为关键驱动因素的作用。 文章详细阐述了 InsR 如何通过高胰岛素血症、胰岛素样生长因子升高和慢性炎症来促进癌症发展。此外，它还阐明了微生物群失调、慢性低度炎症和加速衰老在 InsR 介导的 EOCRC 发展中的复杂相互作用。 最后，该评论呼吁采取早期检测和针对性干预措施，以应对这一日益增长的健康问题。References: Samuel S M, Varghese E, Büsselberg D. Complexity of insulin resistance in early-onset colorectal cancer[J]. Cancer Cell, 2025, 43(5): 797-802.
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