Description
这篇文章探讨了嵌合抗原受体（CAR）T细胞疗法在治疗儿童中枢神经系统（CNS）肿瘤方面的进展和挑战。它概述了当前临床试验的状况，重点介绍了局部给药的潜力，并分析了该疗法面临的解剖学、肿瘤异质性和肿瘤微环境等障碍。文章还讨论了优化CAR T细胞设计和与其他治疗方法（如表观遗传调节剂和免疫检查点抑制剂）相结合的策略。此外，它强调了将以患者为中心的结果纳入试验以及确保治疗可及性的重要性，以期在未来实现更广泛的成功。References: Timpanaro A, Song E Z, Amwas N, et al. Evolving CAR T-Cell Therapy to Overcome the Barriers in Treating Pediatric Central Nervous System Tumors[J]. Cancer Discovery, 2025, 15(5): 890-902.
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