这篇综述挑战了中枢神经系统（CNS）与免疫系统隔离的传统观念。文章解释了脑淋巴系统和脑膜淋巴系统如何清除大脑中的废物和抗原，从而连接中枢神经系统和外周免疫系统。它还讨论了大脑边界处免疫细胞的存在，这些细胞能够呈递中枢神经系统来源的自身肽，形成一种“免疫编码”，旨在通过诱导抑制性T细胞反应来维持中枢神经系统的免疫特权，从而在允许免疫监视的同时限制自身免疫。最后，文章探讨了炎症、衰老和神经退行性疾病如何改变这种免疫编码和淋巴功能，为治疗中枢神经系统疾病提供了新的治疗途径。References: Kim M W, Kipnis J. Glymphatics and meningeal lymphatics unlock the brain-immune code[J]. Immunity, 2025, 58(5): 1040-1051.
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