这篇文章介绍了一种名为“癌症免疫学数据引擎”（CIDE）的新型计算框架，该框架整合了大量免疫治疗患者的组学数据，以期识别在癌症免疫反应中具有关键作用的分泌蛋白。研究人员发现并验证了AOAH（酰基水解酶）作为一种潜在的免疫疗法，能够通过增强T细胞受体功能和保护树突状细胞来提高免疫治疗效果。文章详细阐述了AOAH的作用机制，即通过耗竭免疫抑制性花生四烯酰磷脂酰胆碱及其氧化衍生物来实现。此外，研究还初步探讨了CR1L、COLQ和ADAMTS7等其他分泌蛋白对肿瘤免疫的调控作用，为未来的癌症治疗策略开辟了新的研究方向。References: Gong L, Luo J, Yang E, et al. Cancer immunology data engine reveals secreted AOAH as a potential immunotherapy[J]. Cell, 2025.
No persons identified in this episode.
This episode hasn't been transcribed yet
Help us prioritize this episode for transcription by upvoting it.
Popular episodes get transcribed faster
Other recent transcribed episodes
Transcribed and ready to explore now
Trump $82 Million Bond Spree, Brazil Tariffs 'Too High,' More
16 Nov 2025
Bloomberg News Now
Ex-Fed Gov Resigned After Rules Violations, Trump Buys $82 Mil of Bonds, More
16 Nov 2025
Bloomberg News Now
THIS TRUMP INTERVIEW WAS INSANE!
16 Nov 2025
HasanAbi
Epstein Emails and Trump's Alleged Involvement
15 Nov 2025
Conspiracy Theories Exploring The Unseen
New Epstein Emails Directly Implicate Trump - H3 Show #211
15 Nov 2025
H3 Podcast
Trump Humiliates Himself on FOX as They Call Him Out
15 Nov 2025
IHIP News