本研究概述了传统化疗药物在癌症治疗中的免疫调节作用。传统上，这些药物通过直接杀死癌细胞发挥作用，但现在人们认识到它们还能通过诱导免疫原性细胞死亡和直接影响免疫细胞来刺激抗癌免疫反应。文章探讨了化疗如何增强肿瘤的抗原性并释放危险信号，以及它们如何选择性地影响免疫抑制细胞和活化免疫效应细胞。此外，该研究还讨论了化疗对肠道微生物群和神经内分泌回路的全身影响，这些因素可能影响治疗结果。最后，文章强调了将化疗与免疫检查点抑制剂相结合的潜力，并指出了优化这些联合治疗方案的未来研究方向。References: Galluzzi L, Humeau J, Buqué A, et al. Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors[J]. Nature reviews Clinical oncology, 2020, 17(12): 725-741.
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