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这篇研究聚焦于肿瘤内在因素如何导致癌症免疫疗法（特别是免疫检查点抑制）的耐药性。文章深入探讨了多种机制，包括肿瘤抗原性不足、干扰素-γ信号通路的缺陷以及MHC（主要组织相容性复合体）表达的丧失。此外，研究还详细阐述了致癌信号通路在介导免疫逃逸中的作用，并探讨了克服这些内在耐药性的现有及新兴策略，例如结合疗法和新的免疫增强方法。References: Kalbasi A, Ribas A. Tumour-intrinsic resistance to immune checkpoint blockade[J]. Nature Reviews Immunology, 2020, 20(1): 25-39.
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