这篇综述文章探讨了干细胞如何应对感染、炎症和衰老。文章首先介绍了干细胞在维持组织结构中的核心作用，以及它们通过特异性防御机制（如抗病毒RNA干扰和稳定态下干扰素刺激基因的表达）来保护自身免受病原体侵害，这与分化细胞的先天免疫路径有所不同。其次，文章详细阐述了干细胞与免疫细胞之间双向的相互作用，尤其是在稳态下调节干细胞的增殖和分化，以及在组织损伤或感染后协调组织修复过程中的关键作用。最后，文章分析了炎症衰老（与年龄相关的慢性炎症）如何破坏这种干细胞-免疫相互作用，进而影响组织修复能力并促进整个机体衰老，并指出干细胞本身也可能成为炎症衰老的来源。References: Poirier E Z. How stem cells respond to infection, inflammation and ageing[J]. Nature Reviews Immunology, 2025: 1-12.
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