此项研究深入探讨了嗜中性粒细胞如何通过形成嗜中性粒细胞胞外陷阱 (NETs) 在肿瘤发展中发挥积极作用，特别是在乳腺癌模型中。研究人员发现，这些NETs会导致肿瘤血管闭塞，从而引发肿瘤坏死，而这种坏死并非传统认为的被动过程。更重要的是，位于坏死区域附近的肿瘤细胞表现出上皮-间质转化 (EMT)，这是一种与癌症转移密切相关的过程。通过遗传或药理学手段抑制NETs的形成，可以显著减少肿瘤坏死和肺部转移，这表明针对NETs可能是治疗癌症转移的新策略。References: Adrover J M, Han X, Sun L, et al. Neutrophils drive vascular occlusion, tumour necrosis and metastasis[J]. Nature, 2025: 1-12.
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