这篇研究论文探讨了全基因组倍增（WGD）在高级别浆液性卵巢癌（HGSOC）中如何驱动肿瘤进化和免疫逃逸。研究人员使用了单细胞全基因组测序、单细胞RNA测序和免疫荧光显微镜等多种技术，对41名HGSOC患者的70份肿瘤样本进行了分析。他们发现WGD是一个持续的突变过程，与更高的细胞多样性和染色体错分离率相关。此外，研究揭示了WGD高肿瘤（主要发生WGD）表现出细胞周期失调和免疫抑制状态，而WGD低肿瘤（主要为二倍体）则表现出炎症信号传导和cGAS-STING通路激活。这些发现为理解HGSOC中WGD的作用及其对治疗策略的潜在影响提供了关键见解。References: McPherson A, Vázquez-García I, Myers M A, et al. Ongoing genome doubling shapes evolvability and immunity in ovarian cancer[J]. Nature, 2025: 1-10.
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