这篇研究论文探讨了代谢在酶结构演化中扮演的角色，横跨4亿年，重点关注酿酒酵母亚门。作者利用AlphaFold2预测和实验确定的酶结构，分析了代谢特性的序列差异如何影响从物种专业化到网络组织和酶分子属性的结构演化。研究揭示了酶的催化功能和代谢环境，包括网络架构、生物合成成本和分子相互作用，如何内在性地塑造酶的演化。此外，该研究还发现酶的丰度和通量变异性与结构演化相关，并指出表面残基是成本优化主要发生的位置，而结合位点高度保守且未针对成本进行优化，最终为酶注释和代谢网络工程提供了新策略。References: Lemke O, Heineike B M, Viknander S, et al. The role of metabolism in shaping enzyme structures over 400 million years[J]. Nature, 2025: 1-10.
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