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聊聊Sci

078-小鼠大脑单细胞分辨率立体定位图谱

28 Aug 2025

Description

这篇文章介绍了一种名为STAM(小鼠脑立体定位拓扑图谱) 的新型小鼠脑图谱,其具有1微米各向同性分辨率。该图谱利用连续微光学切片断层扫描技术绘制了整个小鼠大脑的 尼氏染色细胞结构,并整合了多模态图像来构建 916个脑结构的三维地形图。该研究强调了STAM如何克服现有二维图谱和低分辨率三维图谱的局限性,特别是在单细胞水平的空间定位方面。此外,该图谱提供了一个基于信息学的平台,支持脑切片配准、神经回路映射和智能立体定位手术规划等应用,旨在成为神经科学研究中一种多功能的脑信息学工具。References: Feng Z, Li X, Luo Y, et al. A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution[J]. Nature, 2025: 1-9.

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