这项研究深入分析了非吸烟者肺癌（LCINS）的突变模式，利用来自28个地理位置的871名患者的全基因组测序数据。研究人员识别了影响LCINS基因组的多种突变特征，包括一种名为SBS40a的未知来源特征，这种特征在腺癌中最为普遍，并与EGFR突变相关。研究发现不同地理区域的突变类型存在差异，例如，东亚地区的KRAS突变较少，但EGFR和TP53突变较多，而SBS22a特征几乎只在台湾患者中发现。尽管流行病学研究表明二手烟与LCINS有关，但该研究发现二手烟的致突变性较低。然而，研究人员观察到高空气污染地区与更高的TP53突变率、更短的端粒以及包括SBS4和SBS5在内的多种突变类型的增加有关。这些发现强调了环境因素在塑造非吸烟者肺癌基因组中的重要作用。References: Díaz-Gay M, Zhang T, Hoang P H, et al. The mutagenic forces shaping the genomes of lung cancer in never smokers[J]. Nature, 2025: 1-12.
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