这篇研究全面描绘了成年小鼠大脑的细胞类型图谱，通过整合单细胞RNA测序（scRNA-seq）和多重RNA荧光原位杂交（MERFISH）数据，构建了包含34个类别、338个亚类、1201个超类型和5322个细胞簇的层次结构。该图谱不仅详细定义了不同脑区的神经元和非神经元细胞类型，还揭示了它们精确的空间位置及其转录组特征。研究发现转录因子在定义细胞类型身份方面扮演着核心角色，并且细胞类型的转录组身份与空间分布之间存在高度对应关系，为理解大脑复杂的细胞和回路组织提供了基础。这项工作有望促进对脑功能、发育和进化的深入探索，并为未来人类脑疾病的研究提供重要参考。References: Yao Z, Van Velthoven C T J, Kunst M, et al. A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain[J]. Nature, 2023, 624(7991): 317-332.
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