这篇文章详细阐述了利用多重错误鲁棒荧光原位杂交（MERFISH）技术绘制小鼠完整大脑分子定义和空间解析细胞图谱的研究。该研究通过成像约一千万个细胞并整合单细胞RNA测序数据，识别了超过五千个转录上独特的细胞簇，这些簇属于三百多个主要的细胞类型。文中还探讨了神经元和非神经元细胞的多样性与空间组织，分子定义的脑区（空间模块），以及细胞类型特异性的细胞间相互作用，为理解大脑的复杂结构和功能奠定了基础。References: Zhang M, Pan X, Jung W, et al. Molecularly defined and spatially resolved cell atlas of the whole mouse brain[J]. Nature, 2023, 624(7991): 343-354.
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