这篇研究深入探究了成纤维细胞的异质性，整合了来自73项研究的近25万个成纤维细胞数据，构建了一个全面的跨组织单细胞图谱。通过这项工作，研究人员识别并分类了18种成纤维细胞亚型，其中包括此前未被描述的TSPAN8+染色质重塑成纤维细胞。文章阐明了这些亚型在不同组织和肿瘤样本中的分布，并分析了它们与细胞分化、衰老以及与其他细胞的相互作用。此外，该研究还评估了成纤维细胞亚型在癌症预后和免疫治疗反应中的潜在临床意义，并提供了一个用户友好的在线数据平台。References: Liu K, Cui Y, Han H, et al. Fibroblast atlas: Shared and specific cell types across tissues[J]. Science Advances, 2025, 11(14): eado0173.
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