这篇文章深入探讨了骨转移如何通过一种特定机制影响免疫检查点阻断（ICB）免疫疗法的有效性。研究发现，骨转移瘤会诱导破骨细胞产生骨桥蛋白（OPN），这种蛋白通过血液循环远程抑制身体其他部位肿瘤中的T细胞功能。具体来说，OPN会减少前体耗竭T细胞（Tpex）的数量，而Tpex是ICB疗效的关键因素。文章通过小鼠模型和人体临床数据证实，靶向破骨细胞或直接中和OPN可以有效恢复肿瘤对ICB治疗的敏感性，并指出抗RANKL抗体（如地舒单抗）与ICB联合治疗，而非双膦酸盐，能显著改善骨转移患者的治疗预后。References: Cheng J N, Jin Z, Su C, et al. Bone metastases diminish extraosseous response to checkpoint blockade immunotherapy through osteopontin-producing osteoclasts[J]. Cancer Cell, 2025, 43(6): 1093-1107. e9.
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