这篇文章深入探讨了阿尔茨海默病（AD）的细胞和分子基础，特别关注了表观基因组的改变如何影响疾病进展和认知能力。研究人员利用单细胞多区域表观基因组和转录组学技术，分析了AD患者大脑中六个区域的细胞变化。他们发现，疾病进展与表观基因组松弛和信息丢失普遍相关，尤其是在易受损的神经元中。相反，认知弹性与表观基因组的稳定性呈正相关。此外，文章还揭示了小胶质细胞和星形胶质细胞激活与表观基因组动态变化之间的联系，并指出了表观基因组失稳与AD遗传风险之间的内在关联。这些发现为理解AD的发病机制提供了新的见解，并为未来的治疗策略奠定了基础。References: Liu Z, Zhang S, James B T, et al. Single-cell multiregion epigenomic rewiring in Alzheimer’s disease progression and cognitive resilience[J]. Cell, 2025.
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