这篇文章介绍了一种人工智能辅助工具（BEAUT），用于识别肠道微生物中的胆汁酸代谢酶。作者利用BEAUT发现了两种先前未知的酶：MABH（水解单酰化胆汁酸）和ADS（合成一种名为3-acetoDCA的未报告骨架胆汁酸）。研究进一步探索了3-acetoDCA的结构、催化机制及其在人体肠道中的广泛存在，并发现它能促进益生菌乳酸杆菌（Lactobacillus spp.）的生长。这项工作提供了一种自上而下的方法，通过直接探索酶来扩展对微生物胆汁酸代谢及其生物学功能（包括宿主生理和微生物相互作用）的理解。References: Ding Y, Luo X, Guo J, et al. Identification of gut microbial bile acid metabolic enzymes via an AI-assisted pipeline[J]. Cell, 2025.
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