这篇文章揭示了低糖饮食或癌细胞中糖代谢受损如何出人意料地促进肺部肿瘤转移，即使它们能抑制原发肿瘤生长。研究发现，葡萄糖匮乏会通过细胞外囊泡（外泌体）上的一种名为TRAIL的蛋白质，重塑肺部的先天免疫环境。这些外泌体TRAIL会使巨噬细胞极化，导致自然杀伤（NK）细胞耗竭，从而在肺部形成一个有利于肿瘤定植的微环境。此外，文章还指出，血浆外泌体TRAIL可以作为预测早期术后肺转移的准确生物标志物，甚至优于传统指标。References: Wu C Y, Huang C X, Lao X M, et al. Glucose restriction shapes pre-metastatic innate immune landscapes in the lung through exosomal TRAIL[J]. Cell, 2025.
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