Description
这篇文章详细阐述了胆碱能神经元活动在弥漫性中线胶质瘤（DMG）生长中的作用，这是一种侵袭性脑癌。研究表明，中脑胆碱能神经元的活动通过毒蕈碱信号促进DMG细胞和少突胶质细胞前体细胞的增殖。反过来，DMG也会增强胆碱能神经元的活动，形成一个恶性循环。文章还确定了M1和M3毒蕈碱受体是DMG的潜在治疗靶点，因为阻断这些受体可以抑制肿瘤生长。References: Drexler R, Drinnenberg A, Gavish A, et al. Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling[J]. Cell, 2025.
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