这篇研究论文详细描绘了人类大脑皮层在单细胞分辨率下的空间转录组图谱。作者们通过结合单核RNA测序和亚细胞水平的空间转录组测序技术，绘制了14个人类皮层区域的综合细胞图谱。该图谱揭示了神经细胞类型独特的表达模式和空间排列，特别关注了谷氨酸能神经元和GABA能神经元的组织。此外，研究还探索了细胞间的相互作用、配体-受体模式以及皮层区域内神经元-胶质细胞通讯的区域差异。这些发现为理解人类皮层的复杂细胞基础和认知功能，以及未来神经系统疾病的研究提供了宝贵的参考。References: Wei S, Luo M, Wang P, et al. Charting the spatial transcriptome of the human cerebral cortex at single-cell resolution[J]. Nature Communications, 2025, 16(1): 7702.
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