这篇研究利用 单细胞RNA测序 (scRNA-seq) 和 多重成像技术 (CODEX) 详细描绘了人类骨髓的细胞组成和空间结构。研究揭示了 间充质基质细胞 (MSCs) 具有转录和功能上的异质性，并发现了 造血干/祖细胞 (HSPCs) 主要定位于脂肪细胞周围的区域。此外，文章还展示了利用所建立的健康骨髓图谱来理解 急性髓性白血病 (AML) 中MSCs扩增的潜力，以及其在疾病背景下细胞相互作用的变化。这项工作为未来研究人类骨髓微环境提供了重要的参考资源。References: Bandyopadhyay S, Duffy M P, Ahn K J, et al. Mapping the cellular biogeography of human bone marrow niches using single-cell transcriptomics and proteomic imaging[J]. Cell, 2024, 187(12): 3120-3140. e29.
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