Description
这篇文章主要介绍亚洲免疫多样性图谱（AIDA），这是一项对来自五个亚洲国家的健康捐献者的循环免疫细胞进行的多国单细胞参考研究。研究强调了自我报告的种族、遗传祖先、性别和年龄等因素如何显著影响免疫细胞的分子和细胞特性。它还揭示了不同人群中细胞集群的丰度差异，并识别了与疾病相关基因座的特定人群功能变异（eQTLs）。这项工作凸显了研究人类多样性在诊断和精准医疗方面的生物医学价值，特别是考虑到目前基因组数据中亚洲人群代表性不足的问题。References: Kock K H, Han K Y, Ando Y, et al. Asian diversity in human immune cells[J]. Cell, 2025, 188(8): 2288-2306. e24.
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