这项研究介绍了一个名为 OpenCell 的综合性项目，旨在绘制人类细胞组织图谱。研究团队利用 CRISPR 基因编辑技术，构建了一个包含1310个荧光标记细胞系的文库，用于追踪特定蛋白质。通过结合活细胞成像和免疫沉淀-质谱分析 (IP-MS)，他们生成了一个大规模数据集，详细描绘了这些蛋白质在细胞内的定位和相互作用。该研究强调了蛋白质空间分布与功能的高度相关性，并揭示了RNA 结合蛋白独特的组织特征。最终，OpenCell 提供了一个交互式在线资源，以促进对人类蛋白质组架构的进一步探索。References: Cho N H, Cheveralls K C, Brunner A D, et al. OpenCell: Endogenous tagging for the cartography of human cellular organization[J]. Science, 2022, 375(6585): eabi6983.
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