这篇文章讨论了未成熟嗜中性粒细胞在骨转移性肿瘤微环境中的关键作用，及其对抗肿瘤免疫和免疫检查点阻断（ICB）治疗的阻碍。研究发现，DKK1通过DKK1-CKAP4-STAT6-CHI3L3信号通路诱导嗜中性粒细胞呈现未成熟和免疫抑制状态，从而抑制CD8+ T细胞的活化和抗肿瘤功能。通过阻断DKK1，可以促进嗜中性粒细胞成熟，改善免疫微环境，减少肿瘤负荷，并显著增强ICB治疗在骨转移中的疗效。这些发现为骨转移的新型免疫治疗策略提供了依据。References: Shi T, Liu W, Luo Y, et al. CHI3L3+ immature neutrophils inhibit anti-tumor immunity and impede immune checkpoint blockade therapy in bone metastases[J]. Cancer Cell, 2025.
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