这项由全球神经退行性蛋白质组学联盟（GNPC）进行的研究，旨在通过建立一个大型的标准化蛋白质组学数据集来加速神经退行性疾病（如阿尔茨海默病、帕金森病、额颞叶痴呆和肌萎缩性侧索硬化症）的生物标志物和药物靶点发现。该联盟是一个公私合作项目，汇集了来自23个合作伙伴的超过35,000份生物流体样本，包含了大约2.5亿个独特的蛋白质测量数据。通过对这些数据的初步分析，研究人员成功识别出疾病特异性的蛋白质表达差异，发现了反映疾病严重程度的跨诊断蛋白质特征，以及与APOE ε4基因型相关的血浆蛋白质特征。这些发现不仅验证了已知的蛋白质标志物，还提出了新的治疗靶点候选，强调了国际合作和数据共享在推动神经退行性疾病研究中的重要性。该数据集将从2025年7月15日起向更广泛的研究社区开放，以促进未来的研究和药物开发。References: Imam F, Saloner R, Vogel J W, et al. The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging[J]. Nature Medicine, 2025: 1-11.
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