这篇文章提供了一项针对阿尔茨海默病 (AD)、帕金森病 (PD) 和额颞叶痴呆 (FTD) 的大规模血浆蛋白质组学研究的概述。研究分析了来自全球神经退行性疾病蛋白质组学联盟 (GNPC) 的 10,527 份血浆样本，以识别这些神经退行性疾病中共有和疾病特异性的蛋白质标记物和生物学通路。结果表明，PD 和 FTD 表现出最高的蛋白质组学重叠，而 AD 和 PD 的重叠最少。研究还发现，免疫系统、糖酵解和基质相关通路在所有疾病中均富集，同时识别出每个疾病独特的通路和关键调控蛋白质，例如 AD 中的 RPS27A、PD 中的 IRAK4 和 FTD 中的 MAPK1。最终，该研究开发了高特异性的疾病预测模型，突出了血浆生物标志物在神经退行性疾病诊断和治疗策略中的潜力。References: Ali M, Erabadda B, Chen Y, et al. Shared and disease-specific pathways in frontotemporal dementia and Alzheimer’s and Parkinson’s diseases[J]. Nature Medicine, 2025: 1-11.
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