这篇论文深入探讨了脑屏障系统在认知功能、衰老和神经退行性疾病中的作用。研究人员通过分析脑脊液和血浆中的蛋白质水平，揭示了衰老如何导致血脑屏障通透性增加，以及这种变化对认知健康的影响。论文还探讨了性别差异和遗传因素如何影响脑脊液与血浆的蛋白质平衡，并发现了与认知障碍相关的特定蛋白质。这项工作为理解人脑屏障功能障碍提供了分子层面的见解，并对开发靶向脑部的治疗方法具有重要意义。References: Farinas A, Rutledge J, Bot V A, et al. Disruption of the cerebrospinal fluid-plasma protein balance in cognitive impairment and aging[J]. Nature Medicine, 2025: 1-12.
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