这篇文章出自大名鼎鼎的诺奖获得者David Baker组，文章介绍了一种计算设计方法，用于创建具有序列特异性的DNA结合蛋白（DBPs）。它详细说明了DBPs的设计过程，包括构建骨架文库、对接方法和序列优化技术。该研究还通过酵母展示、体外结合分析和X射线共晶体结构等方式验证了所设计DBPs的亲和力和特异性。此外，该论文展示了这些设计的DBPs在大肠杆菌和哺乳动物细胞中调节基因转录的成功应用，突出了其在基因编辑和合成生物学领域的潜力。References: Glasscock C J, Pecoraro R J, McHugh R, et al. Computational design of sequence-specific DNA-binding proteins[J]. Nature Structural & Molecular Biology, 2025: 1-10.
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