这篇科学研究文章探讨了神经系统在癌症生物学中的重要作用，特别是其对癌症转移的贡献。研究人员发现，神经元能够将其线粒体转移给癌细胞，从而增强了癌细胞的代谢适应性和侵袭性。他们开发了一种名为 MitoTRACER 的新型遗传报告系统，用于永久标记接收了神经元线粒体的癌细胞，并进行谱系追踪。通过体内和体外实验，研究表明获得线粒体的癌细胞表现出更高的干性、代谢能力和对转移应激源的抵抗力，这解释了它们在转移部位的富集现象。总之，这些发现揭示了神经系统通过线粒体转移支持癌症代谢和转移扩散的非自主机制。References:Hoover G, Gilbert S, Curley O, et al. Nerve-to-cancer transfer of mitochondria during cancer metastasis[J]. Nature, 2025: 1-11.
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